APPROACHES TO SUBSTANTIATION OF ACCEPTABLE LEVELS IN THE RISK ASSESSMENT PROSESS OF 2,4-D FOR OPERATORS, BYSTANDERS AND POPULATION

Acceptable levels (ALs) are used in the prosess of pesticide risk assessment for operators, bystanders and population. ALs are the final stage of hazard identification and dose-response assessment in risk assessment paradigm. Doses of exposure, which are formed during pesticide application and its behavior in environment, are then compaired with ALs. 2,4-D is group of herbicides on the base of dichlorophenoxiacetic acid. It is widely used in agriculture all over the world to control broad-leaved weeds due to its relatively cheap cost. Its safety is the item of big amount of investigation and discussion. Analysis of 2,4-D physical and chemical properties is given. Full toxicological assessment of available data is discussed, including the delayed effects of 2,4-D and the lack of full dossier. It is suggested to use equitoxicity principle for substantiation of 2,4-D ALs – possibility of identical effect at different routes of exposure. No-effect level in the critical effect at 2,4-D oral administration is used for ALs setting taking into account routes of exposure (the appropriate oral-inhalation and dermal-oral coefficients are used in case of necessity. Different 2,4-D ALs are substantiated for operators, bystanders and common population (self applicants and consumers).

Contribution proposed for:   oral presentation